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WAY-262611

BML-WN110

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DKK1 inhibitor

Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition. TCF-Luciferase EC₅₀=0.63µM. WAY262611 was able to enhance trabecular bone formation rate in the tibia of OVX rats following oral administration.

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Product Details

Alternative Name	(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine
Appearance	Off-white solid.
CAS	123231-07-1
Couple Target	DKK
Couple Type	Inhibitor
Formula	C₂₀H₂₂N₄
MW	318.4
Purity	≥97% (TLC)
Solubility	Soluble in DMSO (30mg/ml) or in 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 6 months after receipt when stored at -20°C.
Handling	Solutions can be stored at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism: Takata, N., Sakakura, E., et al.; Nat. Commun. 8, 1339 (2017), Abstract
(1-(4-Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A wingless b-Catenin Agonist That Increases Bone Formation Rate: J. Pelletier, et al.; J. Med. Chem. 52, 6962 (2009), Abstract

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WAY-262611

BML-WN110

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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