W-7

BML-CA320

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Calmodulin inhibitor

Binds to calmodulin, inhibiting Ca²⁺-calmodulin-regulated enzyme activity. It inhibits the Ca²⁺/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC₅₀=25 µM). Cell permeable.

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Product Details

Alternative Name	N-(6-Aminohexyl)-5-chloro-1-naphtalene-sulfonamide . HCl
Appearance	White to off-white solid.
CAS	61714-27-0
Couple Target	Calmodulin, MLCK
Couple Type	Inhibitor
Formula	C₁₆H₂₁ClN₂O₂S . HCl
MW	377.3
Purity	≥98% (TLC)
Solubility	Soluble in water (warm), methanol, 100% ethanol (10mg/ml) (warm), DMSO (25mg/ml), dimethyl formamide or ethylene glycol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Interleukin-1β processing is dependent upon a calcium-mediated interaction with calmodulin: J.S. Ainscough, et al.; J. Biol. Chem. 290, 31151 (2015), Application(s): Cell culture, Abstract — Full Text
N-Methyl-D-Aspartate Receptor-Dependent Denitrosylation of Neuronal Nitric Oxide Synthase Increase the Enzyme Activity: Z.W. Qu, et al.; PLoS One 7, e52788 (2012), Abstract — Full Text
Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984), Abstract
Calmodulin antagonists’ binding sites on calmodulin.: T. Tanaka, et al.; Pharmacology 26, 249 (1983), Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives.: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981), Abstract
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.: H. Hidaka, et al.; PNAS 78, 4354 (1981), Abstract — Full Text

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W-7

BML-CA320

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