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Vinyl-L-NIO

ALX-270-216

10 citations

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nNOS inhibitor

Very selective and potent neuronal nitric oxide synthase (nNOS/NOS I) inhibitor.

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Product Details

Alternative Name	N5-(1-Imino-3-butenyl)-L-ornithine, L-VNIO
Appearance	Off-white solid to clear film.
CAS	728944-69-2
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₉H₁₇N₃O₂ . HCl
MW	235.7
Purity	≥95% (TLC)
Solubility	Soluble in water, 100% ethanol (30mg/ml), DMSO (50mg/ml) or dimethyl formamide (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Very hygroscopic. Open only in anhydrous atmosphere.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons: Speigel, I., Patel, K., et al.; Neuropharmacology 240, 109705 (2023), Abstract
The Endothelial Dysfunction Could Be a Cause of Heart Failure with Preserved Ejection Fraction Development in a Rat Model: T. Dupas, et al.; Oxid. Med. Cell. Longev. 2022, 7377877 (2022), Abstract
Perivascular Adipose Tissue Anticontractile Function Is Mediated by Both Endothelial and Neuronal Nitric Oxide Synthase Isoforms: Saxton, S. N., Withers, S. B., et al.; J. Vasc. Res. 59, 288 (2022), Abstract
Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats: L.M. Yamaleyeva, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R819 (2007), Abstract
Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries: Y. Hatanaka, et al.; J. Pharmacol. Exp. Ther. 316, 490 (2006), Abstract
Ischemia/reperfusion-induced death of cardiac myocytes: possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia: K. Kawahara, et al.; J. Mol. Cell Cardiol. 40, 35 (2006), Abstract
Myocardial effects of nitric oxide, NO. Clinical and experimental evidence: C. Heymes, et al.; Bull. Acad. Natl. Med. 189, 893 (2005), [Article in French], Abstract
Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines: L.E. Bretscher, et al.; J. Biol. Chem. 278, 46789 (2003), Abstract — Full Text
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000), Abstract — Full Text
N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase: B. R. Babu & O.W. Griffith; J. Biol. Chem. 273, 8882 (1998), Abstract — Full Text

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Vinyl-L-NIO

ALX-270-216

Product Details

Handling & Storage

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