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Vinpocetine

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PDE inhibitor

Selective inhibitor of Ca²⁺/calmodulin-dependent phosphodiesterase (PDE I, IC₅₀=20 µM).

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Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors: K. Molnar-Kimber, et al.; Agents Actions 39, C77 (1993), Abstract
Regulation of cyclic AMP metabolism in bovine adrenal medullary cells: P.D. Marley & K.A. Thomson; Biochem. Pharmacol. 44, 2105 (1992), Abstract
Cyclic 3’,5’-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells: M. Yamaki, et al.; Am. J. Physiol. 262, F957 (1992), Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989), Abstract
Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle: M. Hagiwara, et al.; Biochem. Pharmacol. 33, 453 (1984), Abstract

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