Vindoline

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Lacks physiological activity itself, but is contained as the pentacyclic moiety in the antineoplastic agents vinblastine and vincristine.

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Alternative Name	(2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-Aspidospermidine-3-carboxylic acid methyl ester
Appearance	White to off-white crystalline powder.
CAS	2182-14-1
Formula	C₂₅H₃₂N₂O₆
MI	14: 9988
MW	456.5
Purity	≥90% (assay on dried basis)
RTECS	CJ0120000
Solubility	Soluble in 100% ethanol and water (30mg/ml).
Source	Isolated from Catharanthus roseus.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Very hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Catharanthus roseus L. plants and explants infected with phytoplasmas: alkaloid production and structural observations: M.A. Favali, et al.; Protoplasma 223, 45 (2004), Abstract
Antimitotic agents: chemistry and recognition of tubulin molecule: S. Iwasaki; Med. Res. Rev. 13, 183 (1993), Abstract
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry 30, 873 (1991), Abstract
Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol. 51, 515 (1990), Abstract

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