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Vincristine . sulfate

BML-T117

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Microtubule inhibitor

Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins. Causes aberrant tubulin polymerization. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Posttranscriptionally downregulates HIF-1α expression.

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Product Details

Alternative Name	VCR . sulfate, Leukocristine . sulfate
Appearance	White to off-white powder.
CAS	2068-78-2
Couple Target	HIF, Microtubule
Couple Type	Inhibitor
Formula	C₄₆H₅₆N₄O₁₀ . H₂SO₄
MI	14: 9986
MW	825.0 . 98.1
Purity	≥98% TLC
RTECS	OH6340000
Solubility	Soluble in water (25mg/ml) or methanol.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Low-dose Pimecrolimus, an FDA-approved Calcineurin Inhibitor, Sensitizes Drug-resistant Cancer Cells via Strong P-gp Inhibition: J.H. Park, et al.; Anticancer Res. 43, 1103 (2023), Abstract
Combination Treatment Using Pyruvate Kinase M2 Inhibitors for the Sensitization of High Density Triple-negative Breast Cancer Cells: J.S. Lee, et al.; In Vivo 36, 2105 (2022), Abstract
PKM2 Is Overexpressed in Glioma Tissues, and Its Inhibition Highly Increases Late Apoptosis in U87MG Cells With Low-density Specificity: J.H. Park, et al.; In Vivo 36, 694 (2022), Abstract
Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish: Haney, M. G., Moore, L. H., et al.; J. Vis. Exp. , (2020), Abstract
Novel SIRT1 inhibitor 15-deoxy-Δ12,14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells: Tae, I. H., Park, E. Y., et al.; Int. J. Oncol. 53, 2518 (2018), Abstract
Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition: J.S. Lim, et al.; Anticancer Res. 36, 5063 (2016), Application(s): Cell Treatment, Abstract — Full Text
Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition: A.R. Choi, et al.; Eur. J. Pharmacol. 764, 63 (2015), Application(s): Cell Culture, Abstract
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF: N.J. Mabjeesh, et al.; Cancer Cell 3, 363 (2003), Abstract
Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro: J.A. Vilpo, et al.; Eur. J. Haematol. 65, 370 (2000), Abstract
Vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with acute lymphoblastic leukaemia (ALL): E. Groninger, et al.; Br. J. Haematol. 111, 875 (2000), Abstract

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Vincristine . sulfate

BML-T117

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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