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Verruculogen

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Cell cycle inhibitor

Neurotoxin that acts as an inhibitor of the M phase of the mammalian cell cycle. Inhibits Ca²⁺-activated K⁺ channels. Decreases GABA levels in CNS.

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Appearance	White to off-white powder.
CAS	12771-72-1
Couple Target	Potassium channel
Couple Type	Inhibitor
Formula	C₂₇H₃₃N₃O₇
MW	511.6
Purity	≥95% (HPLC, TLC)
RTECS	JH4920000
Solubility	Soluble in ethyl acetate, DMSO, 100% ethanol or methanol.
Source	Isolated from Penicillium verruculosum.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres.: I. Kosalec, et al.; Acta Pharm. 55, 357 (2005), Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico- chemical properties and structures: C.B. Cui, et al.; J. Antibiot. (Tokyo) 49, 534 (1996), Abstract
Tremorgenic indole alkaloids potently inhibit smooth muscle high- conductance calcium-activated potassium channels: H.H. Knaus, et al.; Biochemistry 33, 5819 (1994), Abstract

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