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Venturicidin A

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Inhibitor of mitochondrial ATP synthase

Macrolide antibiotic. Potent inhibitor of mitochondrial ATP synthase complex, acting on the F₀ membrane sector. Shows antifungal activity.

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Alternative Name	Aabomycin A1
Appearance	White to off-white solid.
CAS	33538-71-5
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₄₁H₆₇NO₁₁
Formulation	Lyophilized.
MI	14: 9947
MW	750.0
Purity	≥95% (HPLC)
RTECS	YX4556000
Solubility	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Source	Isolated from Streptomyces sp. MST-117594.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers: H. Miedema, et al.; BBRC 203, 1005 (1994), Abstract
Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi and Y. Hatefi; J. Biol. Chem. 268, 6168 (1993), Abstract — Full Text
Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance: M. Galanis, et al.; FEBS Lett. 249, 333 (1989), Abstract
Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D.S. Perlin, et al.; Biochim. Biophys. Acta 807, 238 (1985), Abstract
Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature 192, 952 (1961), Abstract

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