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Product Details
| Alternative Name |
Vascular endothelial cadherin, Cadherin-5, CD144, 7B4 antigen |
|---|---|
| Application |
ELISA, Flow Cytometry, ICC, IHC (FS), IP, WB |
| Application Notes |
Detects a band of ~130-140kDa by Western blot. |
| Clone |
BV6 |
| Crossreactivity |
Does not cross-react with other species. |
| Formulation |
Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. |
| Host |
Mouse |
| Immunogen |
Human endothelial cells. |
| Isotype |
IgG2a |
| Purity Detail |
Affinity purified. |
| Recommendation Dilutions/Conditions |
Immunocytochemistry (fluorescence and peroxidase staining)Western Blot (non-reducing)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human |
| UniProt ID |
P33151 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
|---|---|
| Short Term Storage |
+4°C |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation: Buglak, D. B., Bougaran, P., et al.; Elife 12, (2023), Abstract
- RhoGEF17-An Essential Regulator of Endothelial Cell Death and Growth: P. Weber, et al.; Cells 10, 741 (2021), Abstract
- Nuclear SUN1 stabilizes endothelial cell junctions to regulate blood vessel formation: Buglak, D. B., Gold, A. L., et al.; bioRxiv , (2021)
- The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.: Huveneers, S., Zelcer, N., et al.; Cell Rep. 32, 107944 (2020), Application(s): WB / Reactant(s): Human, Abstract
- Endothelial Cell-Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue: TE. Akiyama, et al.; J. Pharmacol. Exp. Ther. 368, 514 (2019), Abstract
- SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4: Lyu, Q., Xu, S., et al.; PNAS 116, 546 (2019), Abstract
- Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions: LA. Wylie, et al.; Dev. Biol. 442, 199 (2018), Abstract
- Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy.: Hu, J., Dziumbla, S., et al.; Nature 552, 248 (2017), Application(s): ICC / Reactant(s): Mouse, Abstract
- EPAC1 promotes adaptive responses in human arterial endothelial cells subjected to low levels of laminar fluid shear stress: Implications in flow-related endothelial dysfunction: S.N. Rampersad, et al.; Cell. Signal. 28, 606 (2016), Application(s): Immunofluorescence, Abstract
- p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin: K. Xiao, et al.; Mol. Biol. Cell 16, 5141 (2005), Abstract — Full Text
- VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells: P. Salven, et al.; Blood 101, 168 (2003), Abstract — Full Text
- Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells: K. Xiao, et al.; J. Cell Biol. 163, 535 (2003), Abstract — Full Text
- Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability: M. Corada, et al.; Blood 97, 1679 (2001), Abstract — Full Text
- Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization: T. Murohara, et al.; J. Clin. Invest. 105, 1527 (2000), Abstract — Full Text
- Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization: P. Navarro, et al.; J. Cell Biol. 140, 1475 (1998), Abstract — Full Text
- Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin): L. Caveda, et al.; J. Clin. Invest. 98, 886 (1996), Abstract — Full Text
- Catenin-dependent and -independent functions of vascular endothelial cadherin: P. Navarro, et al.; J. Biol. Chem. 270, 30965 (1995), Abstract — Full Text
- Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin: F. Breviario, et al.; Arterioscler. Thromb. Vasc. Biol. 15, 1229 (1995), Abstract
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