VAS-2870

BML-EI395

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NADPH oxidase inhibitor

Novel inhibitor of NAD(P)H oxidase (Nox). In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM). VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC₅₀=2µM).

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Product Details

Alternative Name	3-Benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine
Appearance	White to off-white solid.
CAS	722456-31-7
Couple Target	NADPH oxidase
Couple Type	Inhibitor
Formula	C₁₈H₁₂N₆OS
Identity	Determined by NMR.
MW	360.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC: W.J. Lu, et al.; Sci. Rep. 11, 18852 (2019), Abstract — Full Text
Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development: C. Gauron, et al.; Dev. Biol. 414, 133 (2016), Application(s): Zebrafish embryos were incubated in VAS-2870 (Nox-i) (100 nM), Abstract
Detrimental role of pericyte Nox4 in the acute phase of brain ischemia: A. Nishimura, et al.; J. Cereb. Blood Flow Metab. 36, 1143 (2016), Application(s): Cell Culture, Abstract — Full Text
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages: Moon, J. S., Nakahira, K., et al.; Nat. Med. 22, 1002 (2016), Abstract
Bidirectional interactions between NOX2-type NADPH oxidase and the F-actin cytoskeleton in neuronal growth cones: Munnamalai, V., Weaver, C. J., et al.; J. Neurochem. 130, 526 (2014), Abstract
High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases: Zielonka, J., Cheng, G., et al.; J. Biol. Chem. 289, 16176 (2014), Abstract
Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed: Gauron, C., Rampon, C., et al.; Sci. Rep. 3, 2084 (2013), Abstract
H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling: J.F. Wooley, et al.; PLoS One 7, e34050 (2012), Abstract — Full Text
Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein: L.V. d’Uscio, et al.; Cardiovasc. Res. 96, 504 (2012), Application(s): Western Blot of mouse aorta lysates, Abstract — Full Text
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance: Kreisel, D., Sugimoto, S., et al.; Blood 118, 6172 (2011), Abstract

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VAS-2870

BML-EI395

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