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Vancomycin . hydrochloride

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Antibiotic

Glycopeptide antibiotic. Interferes with cell wall synthesis. Effective against Gram-positive bacteria.

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Activity	Potency is >900µg/mg (on dry basis).
Appearance	White to light brown powder.
CAS	1404-93-9
Formula	C₆₆H₇₅Cl₂N₉O₂₄ . HCl
MI	14: 9929
MW	1449.3 . 36.5
RTECS	YW4380000
Solubility	Soluble in water (50mg/ml).
Source	Isolated from Streptomyces lysosup.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Hydrophobic interactions affect hydrogen bond strengths in complexes between peptides and vancomycin or ristocetin: M.P. Williamson & D.H. Williams; Eur. J. Biochem. 138, 345 (1984), Abstract
Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine: G.M. Sheldrick, et al.; Nature 271, 223 (1978), Abstract
Intravitreal injection of vancomycin in experimental staphylococcal endophthalmitis: P. Homer, et al.; Acta Ophthalmol. (Copenh) 53, 311 (1975), Abstract

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