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Valinomycin

BML-KC140

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Potassium ionophore

A potassium ionophore. Induces mitochondrial swelling. Induces apoptosis in CHO cells and other cell lines. Antagonizes endothelin-induced vasoconstriction (IC₅₀=0.3µM).

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Product Details

Appearance	White crystalline solid.
CAS	2001-95-8
Formula	C₅₄H₉₀N₆O₁₈
MW	1111.3
Purity	≥97% (TLC), ≥92% (HPLC)
Solubility	Soluble in 100% ethanol (50mg/ml), acetic acid, chloroform, DMSO or ether.
Source	Isolated from Streptomyces fulvissimus

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue: Watzlawik, J. O., Hou, X., et al.; Autophagy 20, 2076 (2024), Abstract
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue: Watzlawik, J. O., Hou, X., et al.; bioRxiv , (2024)
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples: J.O. Watzlawik, et al.; Autophagy 17, 2613 (2021), Abstract — Full Text
Valinomycin-induced apoptosis in Chinese hamster ovary cells: R. Abdalah, et al.; Neurosci. Lett. 405, 68 (2006), Abstract
Cyclosporin A does not protect the disruption of the inner mitochondrial membrane potential induced by potassium ionophores in intact K562 cells: L.F. Marques-Santos, et al.; Cell Biol. Int. 30, 197 (2006), Abstract
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78: I.-J. Ryoo, et al.; Biol. Pharm. Bull. 29, 817 (2006), Abstract
Valinomycin-induced apoptosis of human NK cells is predominantly caspase independent: A. Paananen, et al.; Toxicology 212, 37 (2005), Abstract
Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification: I.J. Furlong, et al.; Cell Death Differ. 5, 214 (1998), Abstract
Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential: Y. Inai, et al.; Cell. Struct. Funct. 22, 555 (1997), Abstract
Combination of the electrogenic ionophores, valinomycin and CCCP, can lead to non-electrogenic K+/H+ exchange on bilayer lipid membranes: V.N. Orlov, et al.; FEBS Lett. 345, 104 (1994), Abstract

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Valinomycin

BML-KC140

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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