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Ursolic acid

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Inhibits angiogenesis

Inhibits endothelial cell proliferation and migration (IC₅₀=5 µM) and angiogenesis.

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Appearance	White solid.
CAS	77-52-1
Formula	C₃₀H₄₈O₃
MW	456.7
Purity	≥90% (TLC)
Solubility	Soluble in ethanol (5 mg/ml warm) or DMSO (>25 mg/ml warm).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Specific histamine regulating activity of surface-modified yeast vacuoles by histamine- binding protein and its immune-enhancing effect: H. Jang, et al.; Microb. Biotechnol. 15, 2645 (2022), Abstract
Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation: N. Bakhtiari, et al.; Biomed. Pharmacother. 78, 185 (2016), Application(s): In vivo, Abstract
Ursolic Acid Ameliorates Aging-metabolic Phenotype through Promoting of Skeletal Muscle Rejuvenation: N. Bakhtiari, et al.; Med. Hypotheses 85, 1 (2015), Application(s): Injection, Abstract
Triterpenes as potential dimerization inhibitors of HIV-1 protease: L. Quéré, et al.; Biochem. Biophys. Res. Commun. 227, 484 (1996), Abstract
Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds: B.H. Wang & G.M. Polya; Phytochemistry 41, 55 (1996), Abstract
Anti-angiogenic activity of triterpene acids: K.H. Sohn, et al.; Cancer Lett. 94, 213 (1995), Abstract
Inhibition of lipoxygenase activity and HL60 leukemic cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris): A. Simon, et al.; Biochim. Biophys. Acta. 1125, 68 (1992), Abstract

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