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Selectively inhibits monoacylglycerol (MAG) lipase (IC50=28µM) via a noncompetitive mechanism. Does not inhibit FAAH, DAG lipase or COX-2. URB-602 selectively raises levels of 2-arachidonoylglycerol with no change in anandamide concentrationsin cells and tissues. In the same way anandamide levels were markely elevated by the FAAH inhibitor URB597 at 1µM.
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| Regulatory Status |
RUO – Research Use Only |
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