URB-597

BML-EI327

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FAAH inhibitor

URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC₅₀values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID₅₀=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.

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Product Details

Alternative Name	Cyclohexylcarbamic acid 3′-carbamoyl-biphenyl-3-yl ester
Appearance	White solid.
CAS	546141-08-6
Couple Target	FAAH
Couple Type	Inhibitor
Formula	C₂₀H₂₂N₂O₃
MW	338.4
MeltingPoint	155-157°C
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol (1mg/ml), dimethyl formamide (10mg/ml) or DMSO (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutons at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors: X. Viñals, et al.; PLoS Biol. 13, e1002194 (2015), Application(s): Injection into mice, Abstract — Full Text
Endocannabinoids control platelet activation and limit aggregate formation under flow: De Angelis, V., Koekman, A. C., et al.; PLoS One 9, e108282 (2014), Abstract
Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice: Hoyer, F. F., Khoury, M., et al.; J. Mol. Cell. Cardiol. 66, 126 (2014), Abstract
TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception: Giordano, C., Cristino, L., et al.; Cereb. Cortex 22, 2495 (2012), Abstract
Modulation of anxiety through blockade of anandamide hydrolysis: S. Kathuria et al.; Nat. Med. 9, 76 (2003), Abstract
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides: B.F. Cravatt et al.; Nature 384, 83 (1996), Abstract

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URB-597

BML-EI327

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