UPF1035

ALX-270-498

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PARP-2 inhibitor

PARP-2 specific inhibitor with 60-fold selectivity for PARP-2 (IC₅₀=0.15 ± 0.04μM) over PARP-1 (IC₅₀=9.0 ± 0.7μM). Can be used for further characterization of PARP-2 in pathophysiological conditions.

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Product Details

Alternative Name	5-Benzoyloxy-3,4-dihydroisoquinolin-1(2H)-one
CAS	370872-09-6
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₁₆H₁₁NO₃
MW	265.3
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Not stable in basic conditions.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage: F. Moroni, et al.; Br. J. Pharmacol. 157, 854 (2009), Abstract
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives: R. Pellicciari, et al.; ChemMedChem 3, 914 (2008), Abstract

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UPF1035

ALX-270-498

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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