UCN-01

ALX-380-222

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PKC and CDK inhibitor

Inhibitor of protein kinase C (PKC) and cyclin-dependent kinases (CDKs) resulting in accumulation of cells in the G1 phase and induction of apoptosis. Enhances the cytotoxicity of other anticancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these agents.

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Product Details

Alternative Name	7-Hydroxystaurosporine
Appearance	White film.
CAS	112953-11-4
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₈H₂₆N₄O₄
MW	482.5
Purity	≥99% (HPLC)
RTECS	KC6600010
Solubility	Soluble in methanol, 100% ethanol, dimethyl formamide or DMSO.
Source	Isolated from Streptomyces sp. MST-AS5345.
Technical Info / Product Notes	Note: Some interconversion of UCN-01 to UCN-02 may occur under acidic HPLC conditions).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation: Ma, Y., Cui, D., et al.; Mol. Oncol. 13, 307 (2019), Abstract
Dual roles of ERK1/2 in cellular senescence induced by excess thymidine in HeLa cells: I. Kudo, et al.; Exp. Cell. Res. 16, 30205 (2016), Application(s): Cell culture, cervical tumor, Abstract
AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia: Eriksson, A., Kalushkova, A., et al.; Biochem. Pharmacol. 87, 284 (2014), Abstract
UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway: M.M. Facchinetti, et al.; Cancer Res. 64, 3629 (2004), Abstract — Full Text
UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?: S. Akinaga, et al.; Anticancer Drug Des. 15, 43 (2000), Abstract
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line: K. Kawakami, et al.; BBRC 219, 778 (1996), Abstract
UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities: I. Takahashi, et al.; J. Antibiot. (Tokyo) 42, 571 (1989), Abstract
UCN-01, a selective inhibitor of protein kinase C from Streptomyces: I. Takahashi, et al.; J. Antibiot. (Tokyo) 40, 1782 (1987), Abstract

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UCN-01

ALX-380-222

Product Details

Handling & Storage

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