U-83836E

BML-FR101

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Antioxidant

The lazaroid U-83836E prevents hydrogen peroxide-induced F₂ isoprostane production in renal proximal tubular cells and reduces secondary brain injury in a rabbit model of cryogenic trauma.

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Product Details

Alternative Name	(-)-2-((4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol . 2HCl
Appearance	White to off-white solid.
CAS	122003-11-6
Formula	C₃₀H₄₄N₆O₂ . 2HCl
MW	593.6
Purity	≥98% (HPLC)
Solubility	Soluble in water (30 mg/ml) or ethanol (>50 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Propofol Ameliorates Calpain-induced Collapsin Response Mediator Protein-2 Proteolysis in Traumatic Brain Injury in Rats: Y. Yu, et al.; Chin. Med. J. (Engl). 128, 919 (2015), Application(s): Injection in rat, Abstract — Full Text
Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995), Abstract — Full Text
Lazaroids and deferoxamine attenuate the intracellular effects of oxyhaemoglobin in vascular smooth muscle: B. Vollrath, et al.; Cardiovasc. Res. 30, 619 (1995), Abstract
U83836E reduces secondary brain injury in a rabbit model of cryogenic trauma: J. T. Wilson, et al.; J. Trauma 39, 473 (1995), Abstract

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U-83836E

BML-FR101

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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