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U-75302

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Prostanoid receptor ligand

Selective leukotriene B₄ antagonist, K_i=159 nM for inhibition of [³H]-LTB₄ binding to guinea pig lung membranes.

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Appearance	Colorless oil.
CAS	119477-85-9
Couple Target	Leukotriene, Prostanoid receptor
Couple Type	Inhibitor, Ligand
Formula	C₂₂H₃₅NO₃
MW	361.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -80°C for up to 1 year. Store solutions at -80°C for up to 1 month.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1β Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation: Kwak, D. W., Park, D., et al.; Biomedicines 9, (2021), Abstract
Mediatory roles of leukotriene B4 receptors in LPS-induced endotoxic shock: S.Y. Kwon, et al.; Sci. Rep. 9, 5936 (2019), Application(s): Treatment of mice, Abstract — Full Text
The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling: O’Dwyer, C. A., O’Brien, M. E., et al.; J. Immunol. 195, 3628 (2015), Abstract

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