U-73343

BML-ST392

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Phospholipase inhibitor

Inactive analog of U-73122 (Prod. No. BML-ST391) which only slightly inhibits phospholipase C. May be used as a negative control.

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Product Details

Alternative Name	1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-pyrrolidine-2,5-dione
Appearance	White to off-white solid.
CAS	142878-12-4
Couple Target	Lipoxygenase, Phospholipase, PLC
Couple Type	Inhibitor
Formula	C₂₉H₄₂N₂O₃
MW	466.7
Purity	≥98% (HPLC)
Solubility	Soluble in methylene chloride or chloroform; slightly soluble in DMSO (2mg/ml) or 100% ethanol (1mg/ml); sparingly soluble in aqueous solutions.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors: Lavik, A. R., McColl, K. S., et al.; Biochim. Biophys. Acta Mol. Cell Res. 1869, 119206 (2022), Abstract
Effect of selective serotonin (5-HT)2B receptor agonist BW723C86 on epidermal growth factor/transforming growth factor-α receptor tyrosine kinase and ribosomal p70 S6 kinase activities in primary cultures of adult rat hepatocytes: K. Naito, et al.; Biol. Pharm. Bull. 42, 631 (2019), Application(s): used w. adult rat liver hepatocytes, Abstract — Full Text
Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2: Bittremieux, M., La Rovere, R. M., et al.; Cell Death Differ. 26, 531 (2019), Abstract
Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells: Melchior, B., Frangos, J. A., et al.; Am. J. Physiol. Cell Physiol. 303, C467 (2012), Abstract
Comparative Effects of the Endogenous Agonist Glucagon-Like Peptide-1 (GLP-1)-(7-36) Amide and the Small-Molecule Ago-Allosteric Agent Compound 2″ at the GLP-1 Receptor”””: K. Coopman, et al.; J. Pharmacol. Exp. Ther. 334, 795 (2010), Application(s): IP of human embryonic kidney cells, Abstract — Full Text
U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells: A. Tatrai, et al.; Biochim. Biophys. Acta 1224, 575 (1994), Abstract
Gonadotropin-releasing hormone-stimulated intracellular Ca2+ fluctuations and luteinizing hormone release can be uncoupled from inositol phosphate production: B.E. Hawes, et al.; Endocrinology 130, 3475 (1992), Abstract
A new, nongenomic estrogen action: the rapid release of intracellular calcium: P Morley, et al.; Endocrinology 131, 1305 (1992), Abstract
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness: R.J. Smith, et al.; J. Pharmacol. Exp. Ther. 253, 688 (1990), Abstract

Related Products

U-73122

BML-ST391

Inhibitor of PLC activation

28 citations

Alternative Name	1-(6-((17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
CAS	112648-68-7
Couple Type	Inhibitor
Purity	≥98% (HPLC)

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U-73343

BML-ST392

Product Details

Handling & Storage

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