U-46619

BML-PG023

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Prostaglandin H₂/thromboxane A₂ receptor agonist

Potent TP agonist
Used in cardiovascular studies
highly cited

U-46619 is a Prostaglandin H₂/thromboxane A₂ analog and a potent thromboxane A₂ receptor (TP) agonist (EC₅₀ = 0.035µM). U-46619 induces platelet shape change and aggregation at 32nM. U-46619 also activates p38 MAPK.

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Product Details

Alternative Name	9,11-Dideoxy-9α,11α-methanoepoxy prostaglandin F2α, 9,11-Dideoxy-9α,11α-methanoepoxy prosta5Z,13E-dien-1-oic acid
Appearance	Pale yellow oil.
CAS	56985-40-1
Couple Target	p38, Prostanoid receptor, Thromboxane receptor
Couple Type	Activator, Ligand
Formula	C₂₁H₃₄O₄
Identity	Identity determined by 1H-NMR.
MW	350.5
Purity	≥98% (TLC)
Solubility	Soluble in DMF (100mg/ml), DMSO, 100% ethanol, DMSO, or PBS, pH 7.2 (2mg/ml).
Source	Synthetic.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

α-Synuclein is the major platelet isoform but is dispensable for activation, secretion, and thrombosis: A.N. Smith, et al.; Platelets 34, 2267147 (2023), Abstract
MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma: L.S. Danielson, et al.; PLoS One 18, e0278844. (2023), Abstract
Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729: R. Huang, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 395, 471 (2022), Abstract
Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells: A. Tamalunas, et al.; Life Sci. 308, 120931 (2022), Abstract
Long-term administration of resveratrol and MitoQ stimulates cavernosum antioxidant gene expression in a mouse castration model of erectile dysfunction: C.J. Pierre, et al.; Life Sci. 310, 121082 (2022), Abstract
Lenalidomide and pomalidomide inhibit growth of prostate stromal cells and human prostate smooth muscle contraction: A. Tamalunas, et al.; Life Sci. 281, 119771 (2021), Abstract
Bleeding diathesis in mice lacking JAK2 in platelets: N. Eaton, et al.; Blood Adv. 5, 2969 (2021), Abstract
Correlation of Pulse Wave Transit Time with Pulmonary Artery Pressure in a Porcine Model of Pulmonary Hypertension: F. Mueller-Graf, et al.; Biomedicines 9, 1212 (2021), Abstract
Genetic Labeling of Cells Allows Identification and Tracking of Transgenic Platelets in Mice: I. Krüger, et al.; Int. J. Mol. Sci. 22, 3710 (2021), Abstract — Full Text
Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion: S. Stahnke, et al.; Curr. Biol. 31, 2051 (2021), Abstract

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U-46619

BML-PG023

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U-46619

BML-PG023

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