U-37883A

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K⁺ channel blocker

A non-sulfonylurea inhibitor of K-ATP channels. Inhibits vascular K-ATP channels. Inhibits dopamine-modulated potassium channels.

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Alternative Name	N-(1-Adamantyl)-N’-cyclohexyl-4-morpholinecarboxamidine . HCl
Appearance	White to off-white solid
CAS	57568-80-6
Couple Target	Potassium channel
Couple Type	Blocker
Formula	C₂₁H₃₅N₃O . HCl
MW	382
Purity	≥98% (TLC)
Solubility	Soluble in water (5mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 1 month.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of vascular K(ATP) channels by U-37883A: a comparison with cardiac and skeletal muscle: G. C. Wellman, et al.; Br. J. Pharmacol. 128, 909 (1999), Abstract — Full Text
U-37883A potently inhibits dopamine-modulated K+ channels on rat striatal neurons: Y. J. Lin, et al.; Eur. J. Pharmacol. 352, 335 (1998), Abstract

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