U-18666A

A useful tool for inhibition of cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum. Inhibits cholesterol transport in a variety of cell types such as macrophages and sympathetic neurons. May be used to induce a Neimann-Pick disease type C (NPC)or NPC-like phenotype in a variety of cell types. Inhibits cholesterol biosynthesis at the level of oxido-squalene cyclase (OSC). Induction of cataracts is a common toxic feature of OSC inhibitors such as U18666A.