Home Shop Tyrphostin AG 1024

Tyrphostin AG 1024

ALX-270-217

Datasheet
Manual
SDS
CofA

Already have an account?

IGF-1 inhibitor

Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Appearance	Yellow powder.
CAS	65678-07-1
Couple Target	IGF
Couple Type	Inhibitor
Formula	C₁₄H₁₃BrN₂O
MW	305.2
Purity	≥98% (HPLC (UV))
Solubility	Soluble in acetonitrile (5mg/ml), DMSO (8mg/ml), dichloromethane (23mg/ml) or methanol (5mg/ml); insoluble in 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. In a dissolved form it should be stable for at least 1 month.
Handling	Protect from light.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6: Yi, Y. W., You, K., et al.; Int. J. Oncol. 47, 122 (2015), Abstract
Adaptive potentiation in rod photoreceptors after light exposure: McKeown, A. S., Kraft, T. W., et al.; J. Gen. Physiol. 143, 733 (2014), Abstract
BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site: Kang, H. J., Yi, Y. W., et al.; Cell Death Dis. 3, e336 (2012), Abstract
Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells: A. Camirand & M. Pollak; Br. J. Cancer 90, 1825 (2004), Abstract
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins: M. Parrizas, et al.; Endocrinology 138, 1427 (1997), Abstract — Full Text
The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor: M. Ohmichi, et al.; Biochemistry 32, 4650 (1993), Abstract

Last modified: May 29, 2024

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Tyrphostin AG 1024

ALX-270-217

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project