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Tyrphostin AG 1024

ALX-270-217

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IGF-1 inhibitor

Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

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Product Details

Appearance	Yellow powder.
CAS	65678-07-1
Couple Target	IGF
Couple Type	Inhibitor
Formula	C₁₄H₁₃BrN₂O
MW	305.2
Purity	≥98% (HPLC (UV))
Solubility	Soluble in acetonitrile (5mg/ml), DMSO (8mg/ml), dichloromethane (23mg/ml) or methanol (5mg/ml); insoluble in 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. In a dissolved form it should be stable for at least 1 month.
Handling	Protect from light.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6: Yi, Y. W., You, K., et al.; Int. J. Oncol. 47, 122 (2015), Abstract
Adaptive potentiation in rod photoreceptors after light exposure: McKeown, A. S., Kraft, T. W., et al.; J. Gen. Physiol. 143, 733 (2014), Abstract
BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site: Kang, H. J., Yi, Y. W., et al.; Cell Death Dis. 3, e336 (2012), Abstract
Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells: A. Camirand & M. Pollak; Br. J. Cancer 90, 1825 (2004), Abstract
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins: M. Parrizas, et al.; Endocrinology 138, 1427 (1997), Abstract — Full Text
The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor: M. Ohmichi, et al.; Biochemistry 32, 4650 (1993), Abstract

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Tyrphostin AG 1024

ALX-270-217

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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