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Tyrphostin 9

BML-EI215

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PDGF receptor inhibitor

Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC₅₀=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.

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Product Details

Alternative Name	RG-50872, Malonaben, SF 6847
Appearance	Yellow solid.
CAS	10537-47-0
Couple Target	PDGF receptor
Couple Type	Inhibitor
Formula	C₁₈H₂₂N₂O
MW	282.4
Purity	≥99% (HPLC)
RTECS	OO3737000
Solubility	Soluble in DMSO (>25mg/ml) or ethanol (20mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Store tightly sealed in the dark. Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

STF-083010 an inhibitor of IRE1α endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential: Z. Hatokova, et al.; Toxicol. In Vitro 92, 105652 (2023), Abstract
Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens: D. Arbon, et al.; Antimicrob. Agents Chemother. 66, e0072722 (2022), Abstract
An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases: Gahura, O., Mühleip, A., et al.; Nat. Commun. 13, 5989 (2022), Abstract
Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei: Hierro-Yap, C., Šubrtová, K., et al.; J. Biol. Chem. 296, 100357 (2021), Abstract
Chemosensitization of glioblastoma cells to bis-dichloroethyl-nitrosourea with tyrphostin AG17: B.C. Liang & E. Ullyatt; Clin. Cancer Res. 4, 773 (1998), Abstract
The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2: G.A. Palumbo, et al.; Cancer Res. 57, 2434 (1997), Abstract
Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria: A.M. Burger, et al.; Cancer Res. 55, 2794 (1995), Abstract
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci. 12, 171 (1991), Abstract
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells: G.E. Bilder, et al.; Am. J. Physiol. 260, C721 (1991), Abstract
The interaction of highly active uncouplers with mitochondria: H. Terada; Biochim. Biophys. Acta 639, 225 (1981), Abstract

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Tyrphostin 9

BML-EI215

Product Details

Handling & Storage

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