Home Shop Tyrphostin 47 (RG-50864) (AG-213)

Tyrphostin 47 (RG-50864) (AG-213)

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EGFR inhibitor

A potent inhibitor of EGF receptor kinase activity (IC₅₀‘s:EGFR = 2.4 µM, PDGFR = 3.5 µM, p210^bcr-abl=5.9 µM, insulin receptor = 640 µM).

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Appearance	Orange solid.
CAS	122520-86-9
Couple Target	EGFR
Couple Type	Inhibitor
Formula	C₁₀H₈N₂O₂S
MW	220.2
Purity	≥99% (TLC)
Solubility	Soluble at 20 mg/ml in 100% ethanol or DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Product is subject to oxidation. Make solutions fresh daily.
Handling	Store tightly sealed in the dark. Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Tyrosine kinase inhibition: an approach to drug development: A. Levitsk & A. Gazit; Science 267, 1782 (1995), Abstract
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci. 12, 171 (1991), Abstract
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation: R.M. Lyall, et al.; J. Biol. Chem. 264, 14503 (1989), Abstract
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science 242, 933 (1988), Abstract

Last modified: May 29, 2024

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