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Tyrphostin 25 (RG-50875)

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EGFR inhibitor

A potent inhibitor of EGF receptor kinase activity (IC₅₀=3 µM).

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Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Product is subject to oxidation. Make solutions fresh daily.
Handling	Store tightly sealed in the dark. Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro: G. Partik, et al.; J. Cancer Res. Clin. Oncol. 125, 379 (1999), Abstract
Inhibition of GTP-utilizing enzymes by tyrphostins: G. Wolbring, et al.; J. Biol. Chem. 269, 22470 (1994), Abstract
Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines: G. Bergamaschi, et al.; Leukemia 7, 2012 (1993), Abstract
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells: G.E. Bilder, et al.; Am. J. Physiol. 260, C721 (1991), Abstract
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science 242, 933 (1988), Abstract

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