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Tyrphostin 23 (RG-50810)

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EGFR inhibitor

A potent inhibitor of EGF receptor kinase activity (IC₅₀=35 µM).

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Alternative Name	α-Cyano-(3,4-dihydroxy)cinnamonitrile
Appearance	Yellow-tan solid.
CAS	118409-57-7
Couple Target	EGFR
Couple Type	Inhibitor
Formula	C₁₀H₆N₂O₂
MW	186.1
Purity	≥99% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Product is subject to oxidation.
Handling	Store tightly sealed in the dark. Protect from light. Make solutions fresh daily.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex: S. Kapas, et al.; Biochem. J. 305 (Pt2), 433 (1995), Abstract
Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein-tyrosine kinase: R. Seger, et al.; J. Biol. Chem. 270, 28325 (1995), Abstract
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini: R.D. Duan & J.A. Williams; Am. J. Physiol. 267, G401 (1994), Abstract
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation: R.M. Lyall, et al.; J. Biol. Chem. 264, 14503 (1989), Abstract
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science 242, 933 (1988), Abstract

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