Tyrosyl-DNA Phosphodiesterase 1 (human) (recombinant) (His)

TDP1 is catalytically active and will remove a terminal 3’ phosphotyrosyl group from a specifically designed oligo target site (oligo-Tyr). Additionally, TopoGEN scientists have demonstrated that TDP1 will release topo I covalently attached to genomic DNA isolated from cells treated with camptothecin using TopoGEN’s In Vivo Link Kit (Prod. No. TOP-1021).