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TWEAK (soluble) (human), (recombinant)

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Alternative Name	Apo-3L, TNFSF 12
Application Notes	ELISA: binds to FN14 receptor at 10-100 ng/ml.
Biological Activity	Kills TWEAK sensitive cells.
Concentration	0.1mg/ml after reconstitution.
Endotoxin Content	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Formulation	Lyophilized. Contains PBS.
MW	~18-20kDa (SDS-PAGE).
Purity	≥90% (SDS-PAGE)
Reconstitution	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Source	Produced in E. coli. The extracellular domain of human TWEAK (aa 106-249) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG^®-tag.
Specificity	Binds to human and mouse Fn14 (TWEAK-R).
Technical Info / Product Notes	Historical data has shown that TWEAK has a pro-apoptotic effect on several target cell lines, and it induces angiogenesis and proliferation in endothelial cells. FLAG is a registered trademark of Sigma-Aldrich Co.
UniProt ID	O43508

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2: A. Annibaldi, et al.; Mol. Cell 69, 566 (2018), Abstract — Full Text
Non-canonical NFκB activation promotes chemokine expression in podocytes: L. Valino-Rivas, et al.; Sci. Rep. 6, 28857 (2016), Application(s): Cell cultures, renal cells, Abstract — Full Text
Intraovarian TWEAK/Fn14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization: A. De, et al.; Mol. Endocrinol. 20, 2528 (2006), Abstract — Full Text
TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF: H. Xu, et al.; BBRC 318, 422 (2004), Abstract
Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes: L. Jin, et al.; J. Invest. Dermatol. 122, 1179 (2004), Abstract

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