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GlcNAc phosphotransferase inhibitor
Nucleoside antibiotic. Inhibits protein N-glycosylation by blocking the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Induces ER-stress following the inhibition of N-linked glycosylation. Arrests cell cycle in late G1. Unstable at acidic pH.
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Product Details
| Appearance |
White solid to tan solid. |
|---|---|
| CAS |
11089-65-9 |
| Couple Target |
GlcNAc phosphotransferase |
| Couple Type |
Inhibitor |
| Formula |
C38H62N4O16 (Tun B) |
| MI |
14: 9819 |
| MW |
Avg. 840.0 |
| Purity |
≥99% (TLC) |
| Purity Detail |
Mixture of tunicamycin A, B, C and D. |
| RTECS |
YO7980200 |
| Solubility |
Soluble in DMSO (>10mg/ml) or methanol (5mg/ml; warm). |
| Source |
Isolated from Streptomyces lysosuperficus. |
| Technical Info / Product Notes |
Replacement for ADI-908-297. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- CCDC134 controls TLR biogenesis through the ER chaperone Gp96: Bernaleau, L., Drobek, M., et al.; J. Exp. Med. 222, e20240825 (2025), Abstract
- The Aspergillus fumigatus UPR is variably activated across nutrient and host environments and is critical for the establishment of corneal infection: Kamath, M. M., Lightfoot, J. D., et al.; PLoS Pathog. 19, e1011435 (2023), Abstract
- ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation: Chavarria, C., Zaffalon, L., et al.; iScience 26, 107777 (2023), Abstract
- ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells: C. Hagenlocher, et al.; Cell Death Discov. 8, 34 (2022), Abstract
- Analysis of lysosomal hydrolase trafficking and activity in human iPSC-derived neuronal models: Cuddy, L. K., Mazzulli, J. R., et al.; STAR Protoc. 2, 100340 (2021), Abstract
- CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy: Y. Lei, et al.; PLoS One 12, e0183680 (2017), Abstract — Full Text
- Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells: C.A. Tang, et al.; Cancer Res. 76, 2137 (2016), Application(s): Stimulated cells, Abstract — Full Text
- An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response: A. De Gassart, et al.; PNAS 113, E117 (2016), Application(s): Cell culture, Abstract — Full Text
- Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio): S. Faltermann, et al.; Toxins (Basel) 8, 219 (2016), Application(s): EROD assay in Huh7 Cells; Zebrafishliver organ culture and gene expression analysis, Abstract — Full Text
- Estrogen protects SGC7901 cells from endoplasmic reticulum stress-induced apoptosis by the Akt pathway: Fu, Z., Zou, F., et al.; Oncol. Lett. 7, 560 (2014), Abstract
- Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway: K. Shenderov, et al.; J. Immunol. 192, 2029 (2014), Abstract
- Assay development and multivariate scoring for high-content discovery of chemoprotectants of endoplasmic-reticulum-stress-mediated amylin-induced cytotoxicity in pancreatic beta cells: Law, C. J., Ashcroft, H. A., et al.; Assay. Drug Dev. Technol. 12, 375 (2014), Abstract
- Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via UPR signaling: Rico-Bautista, E., Zhu, W., et al.; Oncotarget 4, 1212 (2013), Abstract
- Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition: Hu, J., Dang, N., et al.; Blood 119, 826 (2012), Abstract
- The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue: Kim, J. Y., Tillison, K., et al.; Am. J. Physiol. Endocrinol. Metab. 293, E110 (2007), Abstract
- Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin: T. Yoshida, et al.; Oncol. Rep. 18, 1239 (2007), Abstract
- Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response: C.C. Jiang, et al.; Cancer Res. 67, 5880 (2007), Abstract
- Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor — dioxin responsive element signaling pathway: K. Horikawa, et al.; FEBS Lett. 580, 3721 (2006), Abstract
- Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells: T. Shiraishi, et al.; Cancer Res. 65, 6364 (2005), Abstract
- Tunicamycin inhibits NMDA and AMPA receptor responses independently of N-glycosylation: K. Maruo, et al.; Brain Res. 977, 294 (2003), Abstract
- Tunicamycin inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells: A. Tordai, et al.; BBRC 206, 857 (1995), Abstract
- Role of N-glycosylation in the structure and function of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic leukemia cells: L.H. Matherly & S.M. Angeles; Biochem. Pharmacol. 47, 1094 (1994), Abstract
- Isoprenoids and astroglial cell cycling: diminished mevalonate availability and inhibition of dolichol-linked glycoprotein synthesis arrest cycling through distinct mechanisms: T.J. Langan & M.C. Slater; J. Cell Physiol. 149, 284 (1991), Abstract
- Dolichol-linked glycoprotein synthesis in G1 is necessary for DNA synthesis in synchronized primary cultures of cerebral glia: S. Ishii & J.J. Volpe; J. Neurochem. 49, 1606 (1987), Abstract
- Relationship of the structure and biological activity of the natural homologues of tunicamycin: D. Duksin & W.C. Mahoney; J. Biol. Chem. 257, 3105 (1982), Abstract — Full Text
- Isolation and structures of components of Tunicamycin: T. Ito, et al.; Agric. Biol. Chem. 44, 695 (1980)
- Separation of tunicamycin homologues by reversed-phase high-performance liquid chromatography: W.C. Mahoney & D. Duksin; J. Chromatogr. 198, 506 (1980), Abstract
- Tunicamycin, a new antibiotic. I. Isolation and characterization of tunicamycin: A. Takatsuki, et al.; J. Antibiot. (Tokyo) 24, 215 (1971), Abstract
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