Tubacin

BML-GR362

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HDAC inhibitor

Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6 (IC₅₀=0.004µM). IC₅₀‘s for the other HDACs are 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8. Concentration in cell culture experiments typically ranges from 2-50µM.

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Product Details

Alternative Name	N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanyl]methyl}-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl}phenyl)-N’-hydroxyoctanediamide
Appearance	White solid.
CAS	537049-40-4
Couple Target	HDAC, HDAC6
Couple Type	Inhibitor
Formula	C₄₁H₄₃N₃O₇S
MW	721.9
Purity	≥96% (ELSD)
Solubility	Soluble in DMSO (10 mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -80°C.
Short Term Storage	-20°C
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle: K.I. Jansen, et al.; J. Cell Biol. 222, e202106105 (2023), Abstract
Histone deacetylase-6 modulates the effects of 4°C platelets on vascular endothelial permeability: B. Miyazawa, et al.; Blood Adv. 7, 1241 (2023), Abstract
Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation: Y. Nomura, et al.; Front. Physiol. 12, 675724 (2021), Abstract
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation: Magupalli, V. G., Negro, R., et al.; Science 369, (2020), Abstract
LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma: M. Nassar, et al.; Sci. Rep. 7, 8022 (2017), Application(s): Measurement of cell index against different concentration, Abstract — Full Text
Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects: Gornstein, E. L., Schwarz, T. L., et al.; Exp. Neurol. 288, 153 (2017), Abstract
Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells: Rosik, L., Niegisch, G., et al.; Cancer Biol. Ther. 15, 742 (2014), Abstract
Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner: McCarthy, A. R., Sachweh, M. C., et al.; Mol. Cancer Ther. 12, 352 (2013), Abstract
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin A: K.V. Butler, et al.; J. Am. Chem. Soc. 370, 10842 (2010), Abstract
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents: M. Namdar, et al.; Proc. Natl. Acad. Sci. USA 107, 20003 (2010), Abstract — Full Text

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Tubacin

BML-GR362

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Tubacin

BML-GR362

Product Details

Handling & Storage

Related Products

FLUOR DE LYS® HDAC6 fluorometric drug discovery kit

BML-AK516

HDAC6 (human), (recombinant) (His-tag)

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Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

FLUOR DE LYS^® HDAC6 fluorometric drug discovery kit