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TTFA blocks the respiratory chain complex II causing inhibition of mitochondrial respiration. Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp and Qd. Inhibition of Complex II by TFA has been shown to cause a delay in overall cell cycle progression leading to oxidative stress. TTFA also was found to inhibit porcine liver carboxylesterase.
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Last modified: February 27, 2025