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TSQ (ultra pure)

ENZ-52153

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Zinc dye

TSQ is an efficient membrane-permeable fluorescent probe for zinc (II). It is selective for Zn (II) in the presence of physiological concentrations of Ca (II) and Mg (II) ions. Fluorescence of TSQ is enhanced upon binding Zn (II), but the probe does not demonstrate a shift or change in emission wavelength. TSQ forms a largely insoluble 2:1 (Ligand-Metal) complex with zinc and emits blue light upon excitation at 365 nanometers.

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Product Details

Alternative Name	N-(6-Methoxy-8-quinolyl)-p-toluenesulfonamide
Appearance	Light brown to brown solid.
CAS	109628-27-5
Emission Maximum	385 nm
Excitation Maximum	344 nm
Formula	C₁₇H₁₆N₂O₃S
MW	328.4
Purity	≥98% (LCMS)
Solubility	Soluble in DMSO.
Technical Info / Product Notes	This product is a member of the CELLESTIAL^® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL^® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required.

Handling & Storage

Use/Stability	Stable for at least one year after receipt when stored as recommended. In solvent: – 80°C, 6 months; -20°C, 1 month.
Handling	Protect from light. Keep cool and dry.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Role of Zinc in Axon Formation via the mTORC1 Pathway: S. Choi, et al.; Mol. Neurobiol. 59, 3206 (2022), Abstract
Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ: K. Asahina, et al.; Biol. Trace Elem. Res. , (2021), Abstract
Zinc ionophores isolated from Terminalia bellirica fruit rind extract protect against cardiomyocyte hypoxia/reoxygenation injury: V.L. Bodiga, et al.; Bioorg. Med. Chem. 46, 116394 (2021), Abstract
Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties: S.J. Allison, et al.; Nat. Commun. 12, 3898 (2021), Abstract
Purification of Live Stem-Cell-Derived Islet Lineage Intermediates.: Melton, D. A., Alvarez-Dominguez, J. R., et al.; Curr. Protoc. Stem Cell Biol. 53, e111 (2020), Reactant(s): Human, Abstract
An Inhibitor of the Sodium-Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia: Kang, B. S., Choi, B. Y., et al.; Int. J. Mol. Sci. 21, (2020), Abstract
Effects of Transient Receptor Potential Cation 5 (TRPC5) Inhibitor, NU6027, on Hippocampal Neuronal Death after Traumatic Brain Injury: Park, M. K., Choi, B. Y., et al.; Int. J. Mol. Sci. 21, (2020), Abstract
ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity: Ghazvini Zadeh, E. H., Huang, Z., et al.; Cell Rep. 32, 107904 (2020), Abstract
Live Cell Monitoring and Enrichment of Stem Cell-Derived β Cells Using Intracellular Zinc Content as a Population Marker: Davis, J. C., Helman, A., et al.; Curr. Protoc. Stem Cell Biol. 51, e99 (2019), Abstract
Effects of Protocatechuic Acid (PCA) on Global Cerebral Ischemia-Induced Hippocampal Neuronal Death.: Kho, A. R., Choi, B. Y., et al.; Int. J. Mol. Sci. 19, (2018), Reactant(s): Rat, Abstract