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Tryptanthrin

ALX-270-360

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Inhibitor of prostaglandin and leukotriene synthesis

Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer’s patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. BML-GR319) resistance on breast cancer cells.

Tryptanthrin occurs as a natural product in various plants: Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria, Calanthe discolor, Phaius mishmensis, Strobilanthes cusia.

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Product Details

Appearance	Yellow needles.
CAS	13220-57-0
Couple Target	COX, Lipoxygenase
Couple Type	Inhibitor
Formula	C₁₅H₈N₂O₂
Identity	Determined by 1H-NMR, 13C-NMR, IR, MS and UV.
MW	248.2
Purity	≥98% (1H-NMR, HPLC)
Solubility	Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
Handling	Protect from light and moisture.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway: Liao, X., Zhou, X., et al.; PLoS One 8, e82294 (2013), Abstract
Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells: K. Iwaki, et al.; J. Ethnopharmacol. 134, 450 (2011), Abstract
Modulatory effects and action mechanisms of tryptanthrin on murine myeloid leukemia cells: H.L. Chan, et al.; Cell Mol. Immunol. 6, 335 (2009), Abstract — Full Text
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC 358, 79 (2007), Abstract
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull. 26, 365 (2003), Abstract
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med. 68, 875 (2002), Abstract
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001), Abstract
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol. 407, 197 (2000), Abstract
: H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000)
Tuberculosis: a search for novel therapy starting with natural products: L.A. Mitschler & W. Baker; Med. Res. Rev. 18, 363 (1998), Abstract

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Tryptanthrin

ALX-270-360

Product Details

Handling & Storage

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