Trolox^®

ALX-270-267

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Cell permeable vitamin E derivative

Cell permeable derivative of vitamin E. Antioxidant. Inhibits peroxynitrite mediated tyrosine nitration and mitochondrial proton permeability. Prevents lipid peroxidation, cytotoxicity and apoptosis induced by cytochrome P450 2E1 in HEP G2 cells.

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Product Details

Alternative Name	6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Appearance	White to off-white, pale yellow or pale green powder.
CAS	53188-07-1; 56305-04-5
Formula	C₁₄H₁₈O₄
Identity	Determined by IR.
MW	250.3
Purity	≥96.5% (Titration (T) NaOH 0.1M)
RTECS	DJ2273000
Solubility	Soluble in 100% ethanol (25mg/ml) or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Extracellular matrix-derived peptide stimulates the generation of endocrine progenitors and islet organoids from iPSCs: E.S. Heaton, et al.; J. Tissue Eng. 14, 20417314231185858 (2023), Abstract
Rising levels of antioxidative phyllobilins in stored agricultural produce and their impact on consumer acceptance: C.A. Karg, et al.; NPJ Sci. Food 5, 1038 (2021), Abstract
Angiopoietins stimulate pancreatic islet development from stem cells: S. S. Karanth, et al.; Sci. Rep. 11, 13558 (2021), Abstract
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro 6, ENEURO.0263-18.2019 (2019), Abstract — Full Text
Chemically defined conditions for long-term maintenance of pancreatic progenitors derived from human induced pluripotent stem cells: S. Konagaya, et al.; Sci. Rep. 9, 640 (2019), Abstract
Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway: Kim, E. H., Baek, S., et al.; Oxid. Med. Cell. Longev. 2017, 5498908 (2018), Abstract
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells: N.I. Díaz-Valdivia, et al.; Oncotarget 8, 111943 (2017), Abstract — Full Text
Closed-channel culture system for efficient and reproducible differentiation of human pluripotent stem cells into islet cells: K. Hirano, et al.; Biochem. Biophys. Res. Commun. 487, 344 (2017), Application(s): hiPSC line 253G1, Abstract
Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer: J.L. Roh, et al.; Cancer Lett. 381, 96 (2016), Application(s): Cell viability assays, Abstract
Bactericidal activity of green tea extracts: the importance of catechin containing nano particles: J. Gopal, et al.; Sci. Rep. 6, 19710 (2016), Application(s): Cell culture, Abstract — Full Text

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Trolox^®

ALX-270-267

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Trolox®

ALX-270-267

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Datasheet, Manuals, SDS & CofA

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Trolox^®