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Triptolide

ALX-350-259

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Immunosuppressant

Immunosuppressive agent with anti-inflammatory and antitumor properties. More effective in preventing T cell proliferation and interferon-γ production than FK506 (Prod. No. ALX-380-008). Induces apoptosis in T cells by activating DEVD cleaving caspases. Blocks TNF-α mediated induction of c-IAP1 and c-IAP2 and NF-κB activation. Inhibits induction of MMP-3, MMP-13, and ADAMTS-4 in cell culture.

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Product Details

Alternative Name	PG490
Appearance	White to off-white solid.
CAS	38748-32-2
Couple Target	Caspase
Couple Type	Activator
Formula	C₂₀H₂₄O₆
MW	360.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (1mg/ml) (1h at 37°C).
Source	Isolated from Tripterygium wilfordii.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation: T. Sutani, et al.; Nat. Commun. 6, 7815 (2015), Application(s): Inhibitors , Abstract — Full Text
Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats: L. Liu, et al.; Toxicology 271, 57 (2010), Abstract
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem. 281, 9616 (2006), Abstract
Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells: B.Z. Carter, et al.; Blood 108, 630 (2006), Abstract
Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells: Y. Miyata, et al.; BBRC 336, 1081 (2005), Abstract
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes: A. Liacini et al.; Biochem. Biophys. Res. Commun. 327, 320 (2005), Abstract
Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.: D. Qiu & P.N. Kao; Drugs R. D. 4, 1 (2003), (Review), Abstract
Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506: M.A. Chan, et al.; Phytother. Res. 13, 464 (1999), Abstract
Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T- cells and NF-kappaB transcriptional activation: D. Qiu, et al.; J. Biol. Chem. 274, 13443 (1999), Abstract — Full Text
PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells: K.Y. Lee, et al.; J. Biol. Chem. 274, 13451 (1999), Abstract — Full Text

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ALX-380-008

Immunosuppressant

27 citations

Alternative Name	Tacrolimus
CAS	104987-11-3
Couple Type	Inhibitor, Ligand
Purity	≥98% (HPLC)

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Triptolide

ALX-350-259

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