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TRIP-Br1 monoclonal antibody (TB1-27/2)

ALX-804-645

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TRIP-Br1 (SEI-1) functions as physiological integrator of transcriptional regulatory signals at E2F-responsive promoters to ensure proper execution of E2F-dependent cell cycle progression. TRIP-Br1 is defined as an oncogene.

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This antibody is covered by our Worry-Free Guarantee.

TRIP-Br1 monoclonal antibody (TB1-27/2) Western blot — **Figure 1:** Western blot analysis of pig kidney lysates (LLC-PK1) using MAb to TRIP-Br1 (TB1-27/2) (Prod. No. ALX-804-645) at 1:1’000 and 1:5’000.

Product Details

Alternative Name	Transcriptional regulator interacting with the PHD-bromodomain 1, SEI-1, SERTA domain-containing protein 1, CDK4-binding protein p34SEI1
Application	IHC, IP, WB
Clone	TB1-27/2
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Mouse
Immunogen	Synthetic peptide corresponding to aa 27-42 (D27PGHAAVAQAPPAVAS42) of human TRIP-Br1 [SEI-1].
Isotype	IgG2a
Recommendation Dilutions/Conditions	Immunohistochemistry (1:200)Western Blot (1:1,000-1:5,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from hybridoma tissue culture supernatant.
Species Reactivity	Human, Monkey, Mouse, Porcine
UniProt ID	Q9UHV2
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

SERTAD1 Sensitizes Breast Cancer Cells to Doxorubicin and Promotes Lysosomal Protein Biosynthesis: H.A. Nguyen, et al.; Biomedicines 10, 1148 (2022), Application(s): WB / Reactant(s) Armoracia rusticana, Abstract
Inhibitory role of TRIP-Br1 oncoprotein in anticancer drug-mediated programmed cell death via mitophagy activation.: Jung, S., Myagmarjav, D., et al.; Int. J. Biol. Sci. 18, 3859 (2022), Application(s): ICC-IF, WB, Abstract
The regulation of insulin receptor/insulin-like growth factor receptor ratio, an important factor for breast cancer prognosis, by TRIP-Br1: Jung, S., Mongre, R. K., et al.; Research Square , (2022), Application(s): WB / Reactant(s): Mouse
Inhibitory role of TRIP-Br1/XIAP in necroptosis under nutrient/serum starvation: Z. Sandag, et al.; Mol. Cells 43, 236 (2020), Application(s): WB, Abstract — Full Text
Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines.: Lim, J. S., Yang, Y., et al.; Int. J. Oncol. 48, 2639 (2016), Application(s): WB, Abstract
SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin C cytotoxicity.: Lim, J. S., Yang, Y., et al.; Int. J. Oncol. 46, 1377 (2015), Application(s): WB / Reactant(s): Human, Abstract
Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP.: Lim, J. S., Yang, Y., et al.; Oncotarget 6, 7522 (2015), Application(s): WB, Abstract
TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition.: Lim, J. S., Yang, Y., et al.; Oncotarget 6, 29060 (2015), Application(s): WB, Abstract
Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells: Jung, S., Ohk, J., et al.; Int. J. Oncol. 45, 189 (2014), Abstract
Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.: Lim, J. S., Yang, Y., et al.; Int. J. Oncol. 43, 1587 (2013), Application(s): WB / Reactant(s): Human, Abstract

Last modified: May 29, 2024

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TRIP-Br1 monoclonal antibody (TB1-27/2)

ALX-804-645

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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