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Trinactin

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Cation ionophore

Cation ionophore with high selectivity for ammonium and potassium. Immunosuppressive agent.

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Alternative Name	Antibiotic AKD 1D, Antibiotic S 3466B
Appearance	Colorless film.
CAS	7561-71-9
Formula	C₄₃H₇₀O₁₂
MW	779.0
Purity	≥95% (HPLC)
Solubility	Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Source	Isolated from Streptomyces sp. MST-AS5448.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats: Y. Tanouchi and H. Shichi; Jpn. J. Ophthalmol. 31, 218 (1987), Abstract
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin: S. N. Graven, et al.; Biochemistry 5, 1735 (1966), Abstract
The in Vitro Activity of Nonactin and Its Homologs: Monactin, Dinactin and Trinactin: E. Meyers, et al.; J. Antibiot. (Tokyo) 18, 128 (1965), Abstract

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