Home Shop Trifluoperazine . dihydrochloride

Trifluoperazine . dihydrochloride

ALX-550-310

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Antipsychotic

Facilitates agonist induced elevation of cytosolic calcium at low concentrations (10µM). Antagonizes calmodulin at higher concentrations. Antipsychotic and sedative dopamine antagonist. Potent and irreversible inhibitor of cAMP-gated cationic channels. Inhibits DNA repair. Cell permeable. Potent neurotoxin.

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Product Details

Appearance	White to off-white powder.
CAS	440-17-5
Couple Target	Calmodulin, CNG channel, Dopamine
Couple Type	Inhibitor
Formula	C₂₁H₂₄F₃N₃S . 2HCl
Identity	Identity determined by IR.
MI	14: 9680
MW	407.5 . 73.0
Purity	≥98% (UHPLC)
RTECS	SP1750000
Solubility	Soluble in water (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Urinary Volatile Terpenes Analyzed by Gas Chromatography-Mass Spectrometry to Monitor Breast Cancer Treatment Efficacy in Mice: Woollam, M., Teli, M., et al.; J. Proteome Res. 19, 1913 (2020), Abstract
Trifluoperazine protects brain plasma membrane Ca(2+)-ATPase from oxidative damaging: P. Souza dos Santos, et al.; Exp. Brain Res. 177, 347 (2007), Abstract
The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death: A.G. Polischouk, et al.; Mol. Cancer Ther. 6, 2303 (2007), Abstract
Trifluoperazine stimulates ionizing radiation induced cell killing through inhibition of DNA repair: S. Gangopadhyay, et al.; Mutat. Res. 633, 117 (2007), Abstract
Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor: P.L. Sheets, et al.; J. Neurophysiol. 96, 1848 (2006), Abstract
Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists: S.J. Kleene; Br. J. Pharmacol. 111, 469 (1994), Abstract
Trifluoperazine-induced conformational change in Ca(2+)-calmodulin: M. Vandonselaar, et al.; Nat. Struct. Biol. 1, 795 (1994), Abstract
Trifluoperazine binding to porcine brain calmodulin and skeletal muscle troponin C: J. Massom, et al.; Biochemistry 29, 671 (1990), Abstract
Influence of calmodulin antagonist (stelazine) on agonist-induced calcium mobilization and platelet activation: G.H. Rao; BBRC 148, 768 (1987), Abstract
New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme): H.L. Macfie, et al.; Drug Intel. Clin. Pharm. 15, 94 (1981), Abstract

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Trifluoperazine . dihydrochloride

ALX-550-310

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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