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Trichostatin C

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HDAC inhibitor

Analog of trichostatin A (Prod. No. BML-GR309). Induces acetylation of histone H4. Shows antifungal activity.

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Alternative Name	Antibiotic 145-A
Appearance	White to off-white powder.
CAS	68676-88-0
Couple Target	HAT
Couple Type	Activator
Formula	C₂₃H₃₂N₂O₈
MI	14: 9649
MW	464.5
Purity	≥95% (HPLC)
Solubility	Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Source	Isolated from Streptomyces sp. MST-AS5376.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Promotion of antigen-specific antibody production in murine B cells by a moderate increase in histone acetylation: T. Kohge, et al.; Biochem. Pharmacol. 56, 1359 (1998), Abstract
Effects of trichostatins on differentiation of murine erythroleukemia cells: M. Yoshida, et al.; Cancer Res. 47, 3688 (1987), Abstract — Full Text
Trichostatin C, a glucopyranosyl hydroxamate: N. Tsuji and M. Kobayashi: N. Tsuji and M. Kobayashi; J. Antibiot. (Tokyo) 31, 939 (1978), Abstract

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