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Triacsin C

BML-EI218

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Acyl-CoA synthetase inhibitor

Analog of polyunsaturated fatty acid. Potent inhibitor of long-chain fatty acyl CoA synthetase. Selectively inhibits arachidonoyl-CoA synthetase in intact cells and the nonspecific acyl-CoA synthetase in cell sonicates IC₅₀=3.6-8.7µM. Inhibits neutrophil functions. Blocks β-cell apoptosis induced by fatty acids (lipoapoptosis) and synthesis of triglycerides, diglycerides and cholesterol esters. Potent vasodilator.

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Product Details

Alternative Name	2,4,7-Undecatrienal nitrosohydrazone, 2E,4E,7E-Undecatriene-1-triazene, WS1228A
Appearance	Liquid. In DMSO.
CAS	76896-80-5
Couple Target	Acyl-CoA synthetase
Couple Type	Inhibitor
Formula	C₁₁H₁₇N₃O
MW	207.3
Purity	≥90% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or methanol (5mg/ml).
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for up to 1 year after receipt when stored at -20°C.
Handling	Protect from light. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The Diagnostic Value of ACSL1, ACSL4, and ACSL5 and the Clinical Potential of an ACSL Inhibitor in Non-Small-Cell Lung Cancer: Ma, Y., Nenkov, M., et al.; Cancers (Basel) 16, (2024), Abstract
Francisella tularensis Exploits AMPK Activation to Harvest Host-Derived Nutrients Liberated from Host Lipolysis: S.R. Dominguez, et al.; Infect. Immun. 90, e0015522 (2022), Abstract
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation: Huh, J. Y., Reilly, S. M., et al.; Cell Metab. 32, 1012 (2020), Abstract
Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3: H. Kimura, et al.; J. Lipid Res. 59, 805 (2018), Abstract
Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth: Mulye, M., Zapata, B., et al.; PLoS One 13, e0192215 (2018), Abstract
Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation: M. To, et al.; Mol. Biol. Cell 28, 270 (2017), Abstract
Liver Perilipin5 expression worsens hepatosteatosis but not insulin resistance in high fat fed mice: M.B. Trevino, et al.; Mol. Endocrinol. 29, 1414 (2015), Application(s): Cell culture, Abstract — Full Text
CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase: G. Montero-Moran, et al.; J. Lipid Res. 51, 709 (2010), Abstract
Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages: V. Saraswathi & A.H. Hasty; Arterioscler. Thromb. Vasc. Biol. 29, 1937 (2009), Abstract
The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells: C. Hu, et al.; Cancer Biol. Ther. 7, 131 (2008), Abstract

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Triacsin C

BML-EI218

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