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BML-PD180

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PDE inhibitor

Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll, IC₅₀=0.3nM) in vitro. Potentiates adenosine-stimulated cAMP accumulation.

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Product Details

Alternative Name	9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-[6,1a]-isoquinolin-4-one . HCl, HL 725
Appearance	White to pale yellow solid.
CAS	78416-81-6
Couple Target	PDE
Couple Type	Inhibitor
Formula	C₂₄H₂₇N₃O₃ . HCl
Identity	Determined by 1H-NMR and LC-MS.
MW	405.5 . 36.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml); slightly soluble in water.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +20°C. Solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from moisture.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth: R. An, et al.; Am. J. Cancer Res. 9, 1905 (2019), Abstract — Full Text
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells: M.E. Whalin, et al.; Mol. Pharmacol. 39, 711 (1991), Abstract
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C- mediated pathways: B.A. Konkle, et al.; J. Biol. Chem. 265, 21867 (1990), Abstract — Full Text
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat: F. DeClerck, et al.; Blood Coag. Fibrinol. 1, 247 (1990), Abstract
HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro: D. Rupert & K.U. Weithmann; Life Sci. 31, 2037 (1982), Abstract

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Trequinsin

BML-PD180

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