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trans-Ned-19

ALX-270-503

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Cell permeable, selective and potent inhibitor of nicotinic acid adenine dinucleotide phosphate (NAADP) receptor in mammalian cells and sea urchin eggs. Blocks NAADP signaling. Inhibits Ca²⁺release: trans-Ned-19 (IC₅₀= 6nM); cis-Ned-19 (IC₅₀= 800nM). [³²P] NAADP binding: trans-Ned-19 (IC₅₀= 0.4nM); cis-Ned-19 (IC₅₀= 15µM).Inhibits Ca²⁺ release from lysosomes. Noncompetitive antagonist. Fluorescent.

NAADP (nicotinic acid adenine dinucleotide phosphate) is an emerging Ca2⁺ releasing second messenger in several mammalian tissues including pancreatic, brain and cardiac tissue.

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Product Details

Alternative Name	1-(3-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Appearance	White to off-white powder.
Couple Target	NAADP receptor
Couple Type	Inhibitor
Formula	C₃₀H₃₁FN₄O₃
Identity	Determined by 1H-NMR and MS.
MW	514.6
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO or 100% ethanol.
Source	Synthetic
Technical Info / Product Notes	Fluorescence of Ned-19 is compatible with visualization of the NAADP receptor in intact cells via confocal microscopy using an ultraviolet Argon ion laser (excitation 351 and 365 nm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A Role for Two-Pore Channel Type 2 (TPC2)- Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis?: K.L. Rice, et al.; Contact (Thousand Oaks) 6, 1 (2023), Abstract
Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function: P.P. Y. Lie, et al.; Sci. Adv. 8, eabj5716 (2022), Abstract
NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy: T. Wen, et al.; Cancer Immunol. Res. 10, 162 (2022), Application(s): Treatment of primary human CD8+ T cell culture, Abstract — Full Text
TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons: J.J. Kelu, et al.; Dev. Biol. 438, 57 (2018), Abstract — Full Text
CD38-mediated Ca(2+) signaling contributes to glucagon-induced hepatic gluconeogenesis: S.Y. Rah, et al.; Sci. Rep. 5, 10741 (2015), Application(s): Cell Culture, Abstract — Full Text
Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes: López Sanjurjo, C. I., Tovey, S. C., et al.; PLoS One 9, e111275 (2014), Abstract
Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum: López-Sanjurjo, C. I., Tovey, S. C., et al.; J. Cell Sci. 126, 289 (2013), Abstract
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP: P. Gomez-Suaga, et al.; Hum. Mol. Genet. 21, 511 (2012), Abstract — Full Text
P2Y receptor subtypes evoke different Ca2+ signals in cultured aortic smooth muscle cells: Govindan, S., Taylor, C. W., et al.; Purinergic Signal. 8, 763 (2012), Abstract
NAADP regulates human platelet function: C.H. Coxon, et al.; Biochem. J. 441, 435 (2012), Abstract — Full Text

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trans-Ned-19

ALX-270-503

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