Tranilast

Anti-inflammatory and anti-angiogenic agent. Inhibits VEGF-induced angiogenesis in vivo . Inhibits proliferation and tube formation of human endothelial cells in vitro. Also inhibits smooth muscle cell proliferation and prevents post-angiplasty retsenosis.Synthetic compound with structural similarity to the tryptophan (Trp) catabolites kynurenines. Tranilast ameliorates the disease severity in animal models of multiple sclerosis, in part, by inducing T cell tolerance. Trp degradation is an important mechanism in the maintenance of T cell tolerance in a variety of disease models and is mediated by the rate limiting enzyme indoleamine 2,3-dioxygenase (IDO).