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TRAIL (soluble) (mouse), (recombinant)

BML-SE722

12 citations

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Ligand for TRAIL receptor (DR4, DR5).

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TRAIL (soluble) (mouse), (recombinant) SDS-PAGE — SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 2 µg TRAIL.

Product Details

Alternative Name	Apo-2L, TNFSF 10, CD253
Biological Activity	Induces apoptosis at 0.1 and 1.0µg/ml, in primary cultured mouse hepatocytes, in the presence of cycloheximide (5µg/ml) or actinomycin D (0.5µg/ml). Induces apoptosis in Jurkat cells (a TRAIL-sensitive human cell line) at 1µg/ml, within 3 hours. Inhibits secondary clonal expansion of mouse CD⁸⁺ T cells in vitro (50ng/ml and greater).
Endotoxin Content	<0.1 EU/µg TRAIL, determined using chromogenic Limulus amebocyte lysate (LAL) test.
Formulation	Liquid. In PBS containing 0.1mM DTT.
MW	23 kDa
Purity	≥95% (SDS-PAGE)
Purity Detail	Purified by multi-step chromatography.
Source	Produced in E. coli. Soluble mouse TRAIL (aa 118-291).
UniProt ID	P50591

Handling & Storage

Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Intranasal Administration of a TRAIL Neutralizing Monoclonal Antibody Adsorbed in PLGA Nanoparticles and NLC Nanosystems: An In Vivo Study on a Mouse Model of Alzheimer’s Disease: T. Musumeci, et al.; Biomedicines 10, 985 (2022), Abstract
K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation: Y. Tang, et al.; Nat. Commun. 10, 4157 (2019), Abstract
N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis: Y. Estornes, et al.; Cell Death Dis. 9, 494 (2018), Abstract — Full Text
Targeting Immune Privilege to Prevent Pathogenic Neovascularization: J. Roychoudhury, et al.; Invest. Ophthalmol. Vis. Sci. 51, 3560 (2010), Application(s): Intravitreal injections in mice for studies on choroidal neovascularization, Abstract — Full Text
Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells: A. Lundqvist, et al.; Blood 113, 6120 (2009), Application(s): Death induction of sensitized Renca cells, Abstract — Full Text
IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway: G. Hu & B.J. Barnes; J. Biol. Chem. 284, 2767 (2009), Application(s): Death induction of HCT116 cells, Abstract — Full Text
Treating Metastatic Solid Tumors With Bortezomib and a Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Agonist Antibody: A. Shanker, et al.; J. Natl. Cancer Inst. 100, 649 (2008), Application(s): Death induction of sensitized Renca, TBJ, 4T1 cells, Abstract — Full Text
The role of NF-κB-1 and NF-κB-2-mediated resistance to apoptosis in lymphomas: L. Bernal-Mizrachi, et al.; PNAS 103, 9220 (2006), Application(s): Death induction of 204-3-1, NK-H and NK-92 cells and analysis of resistance to TRAIL-induced cell death of Daudi, SC, F8 and BLA cells, Abstract — Full Text
Keratins Modulate c-Flip/Extracellular Signal-Regulated Kinase 1 and 2 Antiapoptotic Signaling in Simple Epithelial Cells: S. Gilbert, et al.; Mol. Cell Biol. 24, 7072 (2004), Application(s): Death induction of sensitized mouse primary hepatocytes, Abstract — Full Text
TRAIL and KILLER Are Expressed and Induce Apoptosis in the Murine Preimplantation Embryo: J.K. Riley, et al.; Biol. Reprod. 71, 871 (2004), Application(s): Death induction of sensitized mice blastocysts, Abstract — Full Text

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TRAIL (soluble) (mouse), (recombinant)

BML-SE722

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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