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TRAIL, soluble (human) (recombinant) set

ALX-850-018

20 citations

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Product Details

Alternative Name	Apo-2L, TNFSF 10, CD253
Application	FUNC
Application Notes	Induces apoptosis in a concentration range of 1-100ng/ml if applied with the cross-linking enhancer.
Concentration	TRAIL: 0.1mg/ml after reconstitutionEnhancer: 1mg/ml after reconstitution
Contents	10µg of TRAIL, Soluble (human) (recombinant) (Prod. No. ALX-522-003) and 2×50µg of Enhancer for Ligands (Prod. No. ALX-804-034).
Formulation	Lyophilized. Contains PBS.
Purity	≥95% (SDS-PAGE)
Reconstitution	Reconstitute TRAIL with 100µl and each vial of enhancer with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Source	Produced in E. coli. The extracellular domain of human TRAIL (Apo-2L) (aa 95-281) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG^®-tag.
Specific Activity	ED50: 10ng/ml (Jurkat cells)
Specificity	TRAIL binds to human and mouse TRAIL receptors and human osteoprotegerin (OPG).
Technical Info / Product Notes	FLAG is a registered trademark of Sigma-Aldrich Co.
UniProt ID	P50591

Handling & Storage

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells: Rizzo, A., Satta, A., et al.; J. Exp. Clin. Cancer Res. 40, 5 (2021), Abstract
Synergistic anticancer effect of plasma-activated infusion and salinomycin by targeting autophagy and mitochondrial morphology: Ando, T., Suzuki-Karasaki, M., et al.; bioRxiv , (2020)
Q482H mutation of procaspase-8 in acute myeloid leukemia abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization: M. Li, et al.; Biochem. Biophys. Res. Commun. 495, 1376 (2018), Abstract
MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis: Patron, J. P., Fendler, A., et al.; PLoS One 7, e35345 (2012), Abstract
Human mast cells undergo TRAIL-induced apoptosis: B. Berent-Maoz, et al.; J. Immunol. 176, 2272 (2006), Abstract
Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells: S. Lacour, et al.; Oncogene 22, 1807 (2003), Abstract
Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils: I. Daigle, et al.; Nat. Med. 8, 61 (2002), Abstract
Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L): R. Ravi & A. Bedi; Cancer Res. 62, 1583 (2002), Abstract
Induction of TRAIL-mediated glioma cell death by human T cells: J. Dörr, et al.; J. Neuroimmunol. 122, 117 (2002), Abstract
Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells: C. Xiao, et al.; J. Biol. Chem. 277, 25020 (2002), Abstract — Full Text

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TRAIL (soluble) (human), (recombinant)

ALX-522-003

24 citations

Alternative Name	Apo-2L, TNFSF 10, CD253
Purity	≥90% (SDS-PAGE)
Source	Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG^®-tag.

Enhancer for Ligands

ALX-804-034

Enhances biological activity of TRAIL, soluble (human) (recombinant) and FasL, soluble (human) (recombinant).

19 citations

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TRAIL, soluble (human) (recombinant) set

ALX-850-018

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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