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TRAIL-R2 polyclonal antibody

ALX-210-743

20 citations

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This antibody is covered by our Worry-Free Guarantee.

TRAIL-R3 (human) polyclonal antibody image — **Figure**: Specificity of PAb to TRAIL-R2. Lane 1: TRAIL-R3:Fc. Lane 2: TRAIL-R2. ALX-210-743 recognizes a band of approx. 46kDa of the expected size of the recombinant TRAIL-R2:Fc protein in lane 2 and shows no detectable cross-reactivity to TRAIL-R3:Fc in lane 1.”””,TRAIL-R2 polyclonal antibody WB,TRAIL-R2 polyclonal antibody Western Blot,yes
ALX-210-744,210-744.gif,http://static.enzolifesciences.com/fileadmin/files/image/210-744.gif,**Figure**: Specificity of PAb to TRAIL-R3. Lane 1: TRAIL-R3:Fc. Lane 2: TRAIL-R2. ALX-210-744 recognizes an approx. 66kDa band of the expected size of the recombinant TRAIL-R3:Fc protein in lane 1 and shows no detectable cross-reactivity to TRAIL-R2:Fc in lane 2.”””””

Product Details

Alternative Name	TRAIL receptor 2, DR5, Death receptor 5, KILLER, CD262, Trick2, Ly98, TNFRSF10B, TNF-related apoptosis-inducing ligand receptor 2, Tumor necrosis factor receptor superfamily member 10B
Application	Flow Cytometry, ICC, IHC (PS), WB
Application Notes	Detects a band of ~52kDa by Western blot. Cited applications include Immunoprecipitation.
Formulation	Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
Gene/Protein Identifier	8795 (Entrez GeneID)
Host	Goat
Immunogen	Synthetic peptide corresponding to aa 68-94 (A68PQQKRSSPSEGLCPPGHHISEDGRDC94) of the extracellular domain of human TRAIL-R2.
Purity Detail	Epitope-affinity purified IgG.
Quality Control	Western Blot or Immunocytochemistry on cell lines HEK 293 or Jurkat.
Recommendation Dilutions/Conditions	Immunocytochemistry (1:300)Immunohistochemistry (paraffin sections)Western Blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse
UniProt ID	O14763
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Homocysteine potentiates amyloid β -induced death receptor 4- and 5-mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment: Carey, A., Parodi-Rullán, R. M., et al.; Aging Cell 23, e14106 (2024), Abstract
HOMOCYSTEINE POTENTIATES AMYLOID β-INDUCED CEREBRAL ENDOTHELIAL CELL APOPTOSIS, BLOOD BRAIN BARRIER DYSFUNCTION AND ANGIOGENIC IMPAIRMENT: Carey, A., Parodi-Rullán, R., et al.; bioRxiv , (2023), Application(s): WB
Tumor necrosis factor‑related apoptosis‑inducing ligand as a therapeutic option in urothelial cancer cells with acquired resistance against first‑line chemotherapy.: Cinatl, J., Michaelis, M., et al.; Oncol. Rep. 43, 1331 (2020), Application(s): WB / Reactant(s): Human, Abstract
Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL: A. Meijer, et al.; Br. J. Cancer 109, 2685 (2013), Application(s): WB / Reactant(s) Human, Abstract — Full Text
Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells: J.J. Chen, et al.; Oncotarget 3, 833 (2012), Application(s): IHC, Abstract — Full Text
Death receptor 5 signaling promotes hepatocyte lipoapoptosis: S.C. Cazanave, et al.; J. Biol. Chem. 286, 39336 (2011), Application(s): Used for IP and ICC, Abstract
Clinical significance of TRAIL and TRAIL receptors in patients with head and neck cancer: B. Yoldas, et al.; Head Neck 33, 1278 (2011), Abstract
Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis: O. Kutlu, et al.; Int. Urol. Nephrol. 42, 393 (2010), Abstract
Effects of androgen ablation therapy in TRAIL death ligand and its receptors expression in advanced prostate cancer: I.T. Koksal, et al.; Urol. Int. 84, 445 (2010), Abstract
Lack of death receptor 4 (DR4) expression through gene promoter methylation in gastric carcinoma: K.H. Lee, et al.; Langenbecks Arch. Surg. 394, 661 (2009), Abstract

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TRAIL-R2 polyclonal antibody

ALX-210-743

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