Home Shop TRAIL-R2 (human):Fc (human), (recombinant) (FITC conjugate)

TRAIL-R2 (human):Fc (human), (recombinant) (FITC conjugate)

ALX-522-005F

10 citations

Datasheet
Manual
SDS
CofA

Already have an account?

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	DR5, TNFRSF 10B, KILLER, CD262
Application Notes	Flow Cytometry: detection of TRAIL cell surface expression.
Biological Activity	Inhibits human soluble TRAIL-mediated apoptosis.
Concentration	1mg/ml.
Endotoxin Content	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Formulation	Liquid. In PBS containing 0.02% sodium azide.
MW	~46kDa (SDS-PAGE).
Purity	≥95% (SDS-PAGE)
Source	Produced in HEK 293 cells. The extracellular domain of human TRAIL-R2 (DR5) (aa 52-212) is fused to the Fc portion of human IgG1.
Specificity	Binds human and mouse TRAIL.
Technical Info / Product Notes	Historical data has shown inhibition of human soluble TRAIL-induced apoptosis in a concentration range of 0.5-10µg/ml.
UniProt ID	O14763

Handling & Storage

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand: Mucha, S. R., Rizzani, A., et al.; Gut 58, 688 (2009), Abstract
Two adjacent trimeric fas ligands are required for fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003), Abstract — Full Text
Induction of TRAIL-mediated glioma cell death by human T cells: J. Dörr, et al.; J. Neuroimmunol. 122, 117 (2002), Abstract
Death ligand TRAIL induces no apoptosis but inhibits activation of human (auto)antigen-specific T cells: J.D. Lunemann, et al.; J. Immunol. 168, 4881 (2002), Abstract — Full Text
Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand: G. Lu, et al.; J. Immunol. 168, 1831 (2002), Abstract — Full Text
Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in Activated T Cells Abrogates TRAIL-Induced Apoptosis Upstream of the Mitochondrial Amplification Loop and Caspase-8: T.S. Soderstrom, et al.; J. Immunol. 169, 2851 (2002), Abstract
T cells require TRAIL for optimal graft-versus-tumor activity: C. Schmaltz, et al.; Nat. Med. 8, 1433 (2002), Abstract
TRAIL/Apo-2 ligand induces primary plasma cell apoptosis: J. Ursini-Siegel, et al.; J. Immunol. 169, 5505 (2002), Abstract — Full Text
The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation: F. Mühlenbeck, et al.; J. Biol. Chem. 275, 32208 (2000), Abstract — Full Text
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000), Abstract

Related Products

TRAIL-R2 (human):Fc (human), (recombinant)

ALX-522-005

15 citations

Alternative Name	DR5, TNFRSF 10B, KILLER, CD262
Purity	≥95% (SDS-PAGE)
Source	Produced in HEK 293 cells. The extracellular domain of human TRAIL-R2 (DR5) (aa 52-212) is fused to the Fc portion of human IgG1.

TRAIL, soluble (human) (recombinant) set

ALX-850-018

20 citations

Purity	≥95% (SDS-PAGE)

Control:Fc fusion protein (human), (recombinant)

ALX-203-004

Negative control for Fc chimeric proteins

11 citations

Alternative Name	Thy-1 (RLE mutant)
Purity	≥90% (SDS-PAGE)
Source	Produced in HEK 293 cells. The extracellular domain of mutated hThy-1, hThy-1 (RLE) (aa 20-130), is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of hThy-1 has been changed to RLE abolishing the binding of integrins.

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

TRAIL-R2 (human):Fc (human), (recombinant) (FITC conjugate)

ALX-522-005F

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project