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DR5 is a 55kDa member 10B of the TNF receptor superfamily (TNFRSF10B), also known as TRAIL-R2, TRICK2, KILLER, and CD262. It binds the cytotoxic ligand TRAIL and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.
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| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | TRAIL receptor 2, DR5, Death receptor 5, KILLER, CD262, Trick2, Ly98, TNFRSF10B, TNF-related apoptosis-inducing ligand receptor 2, Tumor necrosis factor receptor superfamily member 10B |
|---|---|
| Application | Flow Cytometry |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | TRAIL receptor 2, DR5, Death receptor 5, KILLER, CD262, Trick2, Ly98, TNFRSF10B, TNF-related apoptosis-inducing ligand receptor 2, Tumor necrosis factor receptor superfamily member 10B |
|---|---|
| Application | Flow Cytometry, ICC, IHC (PS), WB |
| Host | Goat |
| Species Reactivity | Human, Mouse |